San Francisco 49ers head coach Kyle Shanahan provided yet another unfortunate injury update on star running back Christian ...

Welcome to the Friday edition of the Pick Six newsletter! I hope everyone remembers to set their alarms for Sunday morning, ...

When Geno Smith stepped to the microphone after another gut-punch of a loss for the Seahawks, this one a 36-24 home defeat to ...

Geno Smith couldn't get the job done for the Seattle Seahawks against the San Francisco 49ers, but his head coach had his ...

San Francisco 49ers withstood a Seattle Seahawks comeback as they beat their NFC West rivals 36-24. The 49ers opened a ...

Brock Purdy connected with George Kittle on two touchdown passes, while Deebo Samuel totaled 117 yards from scrimmage and a ...

What channel is Thursday Night Football on? How to watch NFL Week 6 game between San Francisco 49ers, Seattle Seahawks on TV, ...

The San Francisco 49ers are 3-3 on the season and, more importantly, in first place in the NFC West after a 36-24 win over ...

The San Francisco 49ers' rushing attack presents a big test for the Seattle Seahawks and their struggling defense.

The 49ers and the Seahawks play at 8:15 p.m. ET. Spread favorite: 49ers (-3.5) Over their last five meetings, San Francisco ...

Latest news and live updates as the San Francisco 49ers play the Seattle Seahawks on the road. Follow live as Geno Smith and ...

San Francisco 49ers’ Jordan Elliott (92) blocks a field goal attempt in the second quarter of their NFL game at Levi’s ...